Modifications performed to the Fermenter R1 at the Molecular Immunology Center

Abstract

For high demand in the global market for erythropoietin (EPO) and the inability to grow in new fermentation’s devices, by high costs and services, it is necessary to provide to Molecular Immunology Center (CIM) fermentation’s systems more efficient and that is the objective of our work collective. Among the main problems in this fermenter were: difficulties with some sequences of operation; high risks of operation by the operator as some sequences of operations are performed manually; failures (for automatic operation) in fermentation runs accounted for 65% of total failure of this equipment. This work is related to a series of changes in "software and design" made to the fermenter R1 of the CIM EPOVAC plant, which has reflected a progressive increase in productivity of the fermenter, reaching record production figures.